{
  "seed": 0,
  "test_fraction": 0.2,
  "min_cells": 30,
  "deg_k": 50,
  "n_eval_genes": 2000,
  "eval_gene_selection": "top-2000 by pseudobulk profile variance across control+train perturbations",
  "control_label": "control",
  "pert_column": "perturbation",
  "train_perturbations": [
    "AHR",
    "ARID1A",
    "ARRDC3",
    "ATL1",
    "BAK1",
    "BCORL1",
    "BPGM",
    "CDKN1A",
    "CDKN1C",
    "CEBPA",
    "CEBPE",
    "CELF2",
    "CITED1",
    "CLDN6",
    "CNN1",
    "CNNM4",
    "COL1A1",
    "COL2A1",
    "CSRNP1",
    "DUSP9",
    "EGR1",
    "ELMSAN1",
    "ETS2",
    "FEV",
    "FOSB",
    "FOXA3",
    "FOXO4",
    "HES7",
    "HK2",
    "HNF4A",
    "HOXA13",
    "HOXB9",
    "HOXC13",
    "IER5L",
    "IGDCC3",
    "IKZF3",
    "IRF1",
    "ISL2",
    "JUN",
    "KIAA1804",
    "KIF18B",
    "KIF2C",
    "KLF1",
    "KMT2A",
    "LHX1",
    "LYL1",
    "MAML2",
    "MAP2K3",
    "MAP2K6",
    "MAP4K3",
    "MAP4K5",
    "MAP7D1",
    "MEIS1",
    "NCL",
    "NIT1",
    "OSR2",
    "PLK4",
    "POU3F2",
    "PRDM1",
    "PRTG",
    "PTPN12",
    "PTPN13",
    "PTPN9",
    "RHOXF2",
    "RREB1",
    "RUNX1T1",
    "S1PR2",
    "SAMD1",
    "SET",
    "SGK1",
    "SLC38A2",
    "SNAI1",
    "SPI1",
    "STIL",
    "TBX2",
    "TBX3",
    "TGFBR2",
    "TMSB4X",
    "TP73",
    "TSC22D1",
    "ZBTB1",
    "ZBTB10",
    "ZC3HAV1",
    "ZNF318"
  ],
  "test_perturbations": [
    "BCL2L11",
    "C19orf26",
    "C3orf72",
    "CBFA2T3",
    "CBL",
    "CDKN1B",
    "CEBPB",
    "CKS1B",
    "DLX2",
    "FOXA1",
    "FOXF1",
    "FOXL2",
    "GLB1L2",
    "MAPK1",
    "MIDN",
    "PTPN1",
    "SLC4A1",
    "SLC6A9",
    "UBASH3A",
    "UBASH3B",
    "ZBTB25"
  ],
  "ridge_train_perturbations": [
    "AHR",
    "ARID1A",
    "ARRDC3",
    "ATL1",
    "BAK1",
    "BCORL1",
    "BPGM",
    "CDKN1A",
    "CDKN1C",
    "CEBPA",
    "CEBPE",
    "CELF2",
    "CITED1",
    "CLDN6",
    "CNN1",
    "CNNM4",
    "COL1A1",
    "COL2A1",
    "CSRNP1",
    "DUSP9",
    "EGR1",
    "ELMSAN1",
    "ETS2",
    "FEV",
    "FOSB",
    "FOXA3",
    "FOXO4",
    "HES7",
    "HK2",
    "HNF4A",
    "HOXA13",
    "HOXB9",
    "HOXC13",
    "IER5L",
    "IGDCC3",
    "IKZF3",
    "IRF1",
    "ISL2",
    "JUN",
    "KIF18B",
    "KIF2C",
    "KLF1",
    "KMT2A",
    "LHX1",
    "LYL1",
    "MAML2",
    "MAP2K3",
    "MAP2K6",
    "MAP4K3",
    "MAP4K5",
    "MAP7D1",
    "MEIS1",
    "NCL",
    "NIT1",
    "OSR2",
    "PLK4",
    "POU3F2",
    "PRDM1",
    "PRTG",
    "PTPN12",
    "PTPN13",
    "PTPN9",
    "RHOXF2",
    "RREB1",
    "RUNX1T1",
    "S1PR2",
    "SAMD1",
    "SET",
    "SGK1",
    "SLC38A2",
    "SNAI1",
    "SPI1",
    "STIL",
    "TBX2",
    "TBX3",
    "TGFBR2",
    "TMSB4X",
    "TP73",
    "TSC22D1",
    "ZBTB1",
    "ZBTB10",
    "ZC3HAV1",
    "ZNF318"
  ],
  "ridge_test_perturbations": [
    "BCL2L11",
    "CBFA2T3",
    "CBL",
    "CDKN1B",
    "CEBPB",
    "CKS1B",
    "DLX2",
    "FOXA1",
    "FOXF1",
    "FOXL2",
    "GLB1L2",
    "MAPK1",
    "MIDN",
    "PTPN1",
    "SLC4A1",
    "SLC6A9",
    "UBASH3A",
    "UBASH3B",
    "ZBTB25"
  ],
  "n_other_perturbations_deferred": 131,
  "cells_per_perturbation": {
    "control": 11855,
    "AHR": 558,
    "ARID1A": 232,
    "ARRDC3": 495,
    "ATL1": 379,
    "BAK1": 1457,
    "BCL2L11": 582,
    "BCORL1": 533,
    "BPGM": 464,
    "C19orf26": 872,
    "C3orf72": 264,
    "CBFA2T3": 658,
    "CBL": 663,
    "CDKN1A": 360,
    "CDKN1B": 550,
    "CDKN1C": 230,
    "CEBPA": 460,
    "CEBPB": 488,
    "CEBPE": 1233,
    "CELF2": 475,
    "CITED1": 215,
    "CKS1B": 241,
    "CLDN6": 670,
    "CNN1": 765,
    "CNNM4": 470,
    "COL1A1": 328,
    "COL2A1": 598,
    "CSRNP1": 478,
    "DLX2": 732,
    "DUSP9": 731,
    "EGR1": 322,
    "ELMSAN1": 937,
    "ETS2": 1201,
    "FEV": 704,
    "FOSB": 630,
    "FOXA1": 851,
    "FOXA3": 494,
    "FOXF1": 874,
    "FOXL2": 652,
    "FOXO4": 215,
    "GLB1L2": 463,
    "HES7": 126,
    "HK2": 303,
    "HNF4A": 237,
    "HOXA13": 274,
    "HOXB9": 701,
    "HOXC13": 385,
    "IER5L": 405,
    "IGDCC3": 613,
    "IKZF3": 681,
    "IRF1": 427,
    "ISL2": 582,
    "JUN": 266,
    "KIAA1804": 278,
    "KIF18B": 254,
    "KIF2C": 634,
    "KLF1": 1960,
    "KMT2A": 241,
    "LHX1": 375,
    "LYL1": 432,
    "MAML2": 626,
    "MAP2K3": 579,
    "MAP2K6": 878,
    "MAP4K3": 363,
    "MAP4K5": 366,
    "MAP7D1": 751,
    "MAPK1": 765,
    "MEIS1": 776,
    "MIDN": 298,
    "NCL": 237,
    "NIT1": 192,
    "OSR2": 1003,
    "PLK4": 113,
    "POU3F2": 359,
    "PRDM1": 297,
    "PRTG": 685,
    "PTPN1": 419,
    "PTPN12": 445,
    "PTPN13": 270,
    "PTPN9": 445,
    "RHOXF2": 328,
    "RREB1": 331,
    "RUNX1T1": 779,
    "S1PR2": 541,
    "SAMD1": 498,
    "SET": 986,
    "SGK1": 483,
    "SLC38A2": 332,
    "SLC4A1": 1000,
    "SLC6A9": 558,
    "SNAI1": 467,
    "SPI1": 613,
    "STIL": 309,
    "TBX2": 690,
    "TBX3": 691,
    "TGFBR2": 646,
    "TMSB4X": 543,
    "TP73": 248,
    "TSC22D1": 441,
    "UBASH3A": 819,
    "UBASH3B": 1202,
    "ZBTB1": 693,
    "ZBTB10": 162,
    "ZBTB25": 740,
    "ZC3HAV1": 516,
    "ZNF318": 650
  }
}