OmevraOmevra · Methods
Methods
How Omevra’s numbers are produced: the temporal evaluation, the calibration method, and the evaluation protocol behind every published figure.
Temporal evaluation
How the frozen test set works: fit on ClinVar as of a fixed freeze, then test on variants classified afterwards — the split that cannot leak.
Calibration
How the model’s probabilities are calibrated and checked, per gene and overall — so a stated 0.80 means 0.80.
Evaluation method
The protocol behind every evaluation on this site: fixed task sets, frozen data, and results published in full, including failures.